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KMID : 1098420060140050282
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Korean Journal of Medicinal Crop Science
2006 Volume.14 No. 5 p.282 ~ p.288
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Anti-allergic Activity of Oriental Medicinal Herbs
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Kim Young-Mi
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Abstract
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The effects of extracts from various Oriental medicinal herbs on mast-cell-mediated allergic reactions were investigated in this study. Out of these extracts, the medicinal herb Atractylodis rhizoma alba exhibited the most potent activity in the cells, with IC_50 values of 20.5;{mu}g/ml, by DNP-BSA and 33.04;{mu}g/ml, by compound 48/80. Similar to the in vitro activity, Atractylodis rhizoma alba inhibited compound-48/80-induced systemic anaphylaxis by 31.3% at 300 mg/kg in mice. It also suppressed the secretion of TNF-{alpha}, a major pro-inflammatory cytokine in the cells. These results may suggest that Atractylodis rhizoma alba shows anti-allergic activity in compound 48/80-induced anaphylactic mice through the inhibition of mast cells.
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KEYWORD
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Atractylodis rhizoma alba, mast cells, anti-allergic activity
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